Natural Approaches To Being In A Better Mood: Some might argue otherwise, but it’s a biological reality that females are much more likely than males to become overly upset, perturbed, or downright angry over issues that really shouldn’t be given the severity they are. In truth, it all comes down to a woman’s brain biochemistry in part, and equally so for the fact that we’re also much more inclined to hang on to those upsetting issues and be in ‘a bad mood’ much more often and for longer periods of time.